文章摘要
引用本文:刘 凯,郑 娜,林旭聪,吕海霞.奎宁功能化的混合模式有机-硅胶杂化整体柱的制备和应用[J].福州大学学报(自然科学版),2018,46(2):242~246
奎宁功能化的混合模式有机-硅胶杂化整体柱的制备和应用
Preparation and application of aquinine functionalized organic-silica hybrid monolithic column with a mix-mode
  
DOI:10.7631/issn.1000-2243.17109
中文关键词: 杂化柱  奎宁  混合模式  毛细管电色谱
英文关键词: hybrid monolithic column  quinine  mixed-mode  capillary electrochromatography
基金项目:
作者单位
刘 凯 福州大学材料科学与工程学院福建 福州 350116 
郑 娜 福州大学化学学院福建 福州 350116 
林旭聪 福州大学化学学院福建 福州 350116 
吕海霞 福州大学材料科学与工程学院福建 福州 350116 
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中文摘要:
      在氯丙基硅胶整体柱固定相表面,通过亲核反应衍生奎宁功能单体,制备新型混合模式有机-硅胶杂化整体柱. 实验考察杂化整体柱的结构特征和电色谱性能,结果表明衍生奎宁后的杂化整体柱结构均匀,重现性良好,在酸性条件下产生较大的反向电渗流. 整体柱通过对极性小分子、多环芳烃及有机酸类物质的分离,体现出明显的反相作用、π-π作用和阴离子交换作用. 在混合模式作用下,成功分离了碱性的烟碱类化合物.
英文摘要:
      A new mixed-mode organic-silica hybrid monolithic column was prepared by derivating quinine onto the chloropropyl-functionalized silica monolith via nucleophilic reaction. The structure characteristics and chromatographic performance of the hybrid column were studied,the results showed that the hybrid column has homogenous morphology and good reproducibility,and a reverse electroosmotic flow(EOF) was generated at acidic conditions. Multiple retention mechanisms including reversed-phase chromatographic behavior,π-π interactions and anion-exchange interactions were studied by separating various kinds of analytes,such as small polar molecules,polycyclic aromatic hydrocarbons and organic acids. And the hybrid column can effectively separate alkaline nicotinic compounds under mixed-mode by multiple separations.
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