文章摘要
引用本文:胡 佳,赖源发,陈君怀,庄峙厦.单片式面膜中6种防腐剂的高效液相色谱法测定[J].福州大学学报(自然科学版),2016,44(2):273~276
单片式面膜中6种防腐剂的高效液相色谱法测定
Simultaneous determination of six preservatives in facial mask by high performance liquid chromatography
  
DOI:
中文关键词: 高效液相色谱法  防腐剂  面膜
英文关键词: high performance liquid chromatography  preservative  facial mask
基金项目:
作者单位
胡 佳 厦门华厦学院检验科学与技术系福建 厦门 361024 
赖源发 厦门华厦学院检验科学与技术系福建 厦门 361024 
陈君怀 厦门华厦学院检验科学与技术系福建 厦门 361024 
庄峙厦 厦门大学化学化工学院 福建 厦门 361005 
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中文摘要:
      建立了同时测定单片式面膜中苯甲酸、山梨酸、脱氢乙酸、苯氧乙醇、氯苯甘醚和碘丙炔醇丁基氨甲酸酯6种防腐剂的高效液相色谱方法. 面膜经50%(体积分数)甲醇提取,采用C18色谱柱,以甲醇和乙酸铵溶液(0.02mol·L-1)为流动相进行梯度洗脱,流速为1.0mL·min-1,柱温30℃,苯甲酸、山梨酸、氯苯甘醚、苯氧乙醇和碘丙炔醇丁基氨甲酸酯的检测波长为235nm,脱氢乙酸的检测波长为295nm. 6种防腐剂浓度在0.5~20μg·mL-1范围内与峰面积均呈现良好的线性关系,方法的加标回收率为88.1%~105.3%,相对标准偏差为1.7%~2.8%. 方法操作简便、快速, 重复性好,灵敏度高,可用于面膜中6种防腐剂的测定.
英文摘要:
      The high performance liquid chromatographic method was developed for the simultaneous determination of six preservatives ( benzoic acid, sorbic acid, dehydro acetic, phenoxyethano, chlorphenesin, iodopropynyl butylcarbamate) in facial mask. The samples were extracted with 50% (volume fraction)methanol, and then separated on a C18 chromatographic column by gradient elution at a flow rate of 1.0mL·min-1 with methanol-ammonium acetate solution as the mobile phase. The column temperature was 30℃. The wavelength of detection for benzoic acid, sorbic acid, phenoxyethano, chlorphenesin, iodopropynyl butylcarbamate was 235nm, but for dehydroacetic acid was 295nm. In the range of 0.5 to 20μg·mL-1 the peak area of six preservatives showed a good linear relationship, the recoveries were 88.1% to 105.3% with the relative standard deviations 1.7% to 2.8%. The method is simple, rapid, accurate and sensitive, which can be used for determination of six preservatives in facial mask.
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